Douglas A. Cotanche

Douglas A. Cotanche


Start Year: 
1985
Department: 
Dept. of Anat. & Cell Biology
Institution: 
University of Illinois at Chicago Medical School
Current Institution: 
University of Illinois at Chicago Medical School

My summer as a Grass Fellow (1985) was probably one of the most productive and career-changing three months of my life. My work in collaboration with Jeff Corwin led to the discovery of hair cell bundle reorientation during development and to the eventual discovery of hair cell regeneration in the avian cochlea. Both of these discoveries have radically changed the direction of the entire field of hearing research since then. This seminal work went on to influence a whole new field defining PCP gene pathways in the developing chick and mouse cochlea. Our work on the discovery of hair cell regeneration was published in Science in 1988 and although it doesn't specifically mention support from the Grass Foundation, it probably should have. Most of the ideas and future studies Jeff and I did together on regeneration had their initial formulation that summer in Woods Hole. Well, it turns out I forgot to include the work that Jeff and I did that summer that was actually what we got funded for in the first place by the Grass Foundation! We were able to show that embryonic hair cells developed their correct tonotopic features completely independently of innervation by culturing denervated chick cochlea and tracking the differentiation of their position-specific tonotopic stereocilia morphologies. This work eventually led to the current research on the inherent genetic control of hair cell differentiation within the sensory epithelium that has been such an exciting finding in recent work on hair cell development. Prior to our discovery, the field assumed that the cochlear nerves primarily influenced and regulated the development of hair cells and their tuning characteristics and that the hair cells were just passive recipients of the critical developmental signals.

input:focus, select:focus, textarea:focus { border-color: #2d3e50; } a { color: #2d3e50; } .radio i, .checkbox i { color: #2d3e50; } .radio i:before { background-color: #2d3e50; } .button, .btn-default { border-color: #2d3e50; background-color: #2d3e50; } .button:hover { color: #2d3e50; } .page-header-top { background-color: #2d3e50; } .page-header-bottom-alt { background-color: #2d3e50; } .page-intro:after { background-color: #2d3e50; } .page-intro:before { background-color: #2d3e50; } .page-content-section-bg { background-color: #2d3e50; } .page-content-section-bg:before { background-color: #2d3e50; } .page-content-section-border { border-top-color: #2d3e50; } .page-footer { background-color: #2d3e50; } .block-head-1 { border-bottom-color: #2d3e50; } .block-head-1 i { background-color: #2d3e50; } .block-head-2:after { background-color: #2d3e50; } .block-head-2 i:after, .block-head-2 i:before { background-color: #2d3e50; } .block-head-3 { border-bottom-color: #2d3e50; } .block-head-3 i:after { background-color: #2d3e50; } .block-head-4:after { background-color: #2d3e50; } .block-head-7 { border-bottom-color: #2d3e50; } .block-head-7:after { background-color: #2d3e50; } .page-content-section-bg .block-head-3 i { color: #2d3e50; } .main-search button { color: #2d3e50; } .main-search button:after { background: #2d3e50; } .main-nav li a { color: #2d3e50; } .main-nav li a:before { background-color: #2d3e50; } .main-nav li ul { background-color: #2d3e50; } .main-nav li li:hover > a, .main-nav li li.active > a, #block-newsletter-newsletter-subscribe .form-submit:hover, .block-product-details .add-wishlist .button-alt:hover, .block-product-details-2 .add-wishlist .button-alt:hover { color: #2d3e50; } .main-nav .switcher { border-color: #2d3e50; background-color: #2d3e50; } .main-nav .mega > div { background-color: #2d3e50; } #block-newsletter-newsletter-subscribe .form-submit, .btn-primary:hover, .btn-primary:focus, .btn-primary:active { border-color: #2d3e50; background-color: #2d3e50; } .art-portfolio ol li.active, .ui-slider-horizontal .ui-slider-handle, .ui-slider-horizontal .ui-slider-range, .btn-primary.link { background-color: #2d3e50; } .btn-primary, .button:hover, .btn-default:hover, .btn-default:focus, .btn-default:active { border-color: #2d3e50; color: #2d3e50; } .btn-primary.link:hover, .btn-primary.link:focus, .btn-primary.link:active { color: #2d3e50; } } @media screen and (max-width: 767px) { /* phone */ .main-nav ul { background-color: #2d3e50; } .main-nav li a { color: #ecf0f1; } .main-nav li ul { background: #e9e9e9; } .main-nav li li { border-top-color: #2d3e50; } .main-nav li li a { color: #2d3e50; } .main-nav li li a:hover { background-color: #2d3e50; color: #fff; } .main-nav li li ul { border-top-color: #2d3e50; } .main-nav .mega ul li { border-top-color: #2d3e50; } } .slider-revolution .fa:after { background-color: #2d3e50; } .slider-revolution .title { border-top-color: 1px solid #2d3e50; border-bottom-color: 1px solid #2d3e50; } .slider-revolution .button-my { border-color: #2d3e50; background-color: #2d3e50; } .slider-revolution .button-my:hover { color: #2d3e50; } .pagination-1 a:hover { border-color: #2d3e50; color: #2d3e50; } .pagination-1 .active, .pagination-1 .active:hover { border-color: #2d3e50; background: #2d3e50; } .pagination-2 a:hover { color: #2d3e50; } .pagination-2 .active, .pagination-2 .active:hover { background: #2d3e50; } .pagination-3 a:before { box-shadow: inset 0 0 0 1px #2d3e50; } .pagination-3 .active:before, .pagination-3 .active:hover:before { background: #2d3e50; } .pagination-4 a:hover { border-color: #2d3e50; } .pagination-4 .active { border-color: #2d3e50; background: #2d3e50; } .pagination-5 a { border-color: #2d3e50; background-color: #2d3e50; color: #2d3e50; } .block-benefits div:hover { border-color: #2d3e50; background-color: #2d3e50; } .block-benefits i { color: #2d3e50; } .block-benefits-2 li i { color: #2d3e50; } .block-benefits-2 .tabs a:hover { border-color: #2d3e50; background-color: #2d3e50; } .block-benefits-2 .tabs .active a, .block-benefits-2 .tabs .active a:hover { color: #2d3e50; } .block-benefits-3 i { color: #2d3e50; } .block-about .button { border-color: #2d3e50; color: #2d3e50; } .block-about .button:hover { background: #2d3e50; color: #ecf0f1; } .block-about .owl-prev:hover, .block-about .owl-next:hover { color: #2d3e50; } .block-about-2 .bar { background: #2d3e50; } .block-about-2 .value { color: #2d3e50; } .block-about-4 .owl-pagination div { border-color: #2d3e50; background: #2d3e50; } .block-about-5 .owl-prev, .block-about-5 .owl-next { display: inline-block; border-color: #2d3e50; background-color: #2d3e50; } .block-about-5 .owl-prev:hover, .block-about-5 .owl-next:hover { color: #2d3e50; } .block-about-6 .icons a:hover { color: #2d3e50; } .block-mission .year { background: #2d3e50; } .block-mission .years a:after { border-bottom-color: #2d3e50; } .block-recent-works ol li:hover { color: #2d3e50; } .block-recent-works ol .active { border-color: #2d3e50; background: #2d3e50; } .block-recent-works .description { background: #2d3e50; } .block-recent-works .description:before { border-right-color: #2d3e50; } .block-recent-works-3 h3 { border-top-color: #2d3e50; } .block-recent-works-3 .link { border-color: #2d3e50; } .block-recent-works-3 .fancybox { background-color: #2d3e50; } .block-recent-works-3 .owl-pagination div { border-color: #2d3e50; background: #2d3e50; } .block-recent-works-4:before { background: #2d3e50; } .block-recent-works-4 .fancybox { background: #2d3e50; } .block-recent-works-4 .owl-prev:hover, .block-recent-works-4 .owl-next:hover { color: #2d3e50; } .block-recent-works-6 a:before { background: #2d3e50; } .block-recent-works-6 .owl-prev, .block-recent-works-6 .owl-next { border-color: #2d3e50; background: #2d3e50; } .block-recent-works-6 .owl-prev:hover, .block-recent-works-6 .owl-next:hover { color: #2d3e50; } .block-portfolio ol li:hover { color: #2d3e50; } .block-portfolio ol li.active { border-bottom-color: #2d3e50; } .block-portfolio ul .pic span:after, .block-portfolio ul .pic span:before { background: #2d3e50; } .block-portfolio ul .pic span i { color: #2d3e50; } .block-portfolio-2 ol li:hover { color: #2d3e50; } .block-portfolio-2 ol li.active { background: #2d3e50; } .block-portfolio-2 ul .pic:before { background: #2d3e50; } .block-portfolio-2 ul .pic a { background: #2d3e50; } .block-portfolio-2 ul .pic a:hover { color: #2d3e50; } .block-portfolio-3 ol li:hover { color: #2d3e50; } .block-portfolio-3 ol li.active { background: #2d3e50; } .block-portfolio-4 h3 { border-top-color: #2d3e50; } .block-portfolio-4 .link { border-color: #2d3e50; } .block-portfolio-4 .fancybox { background: #2d3e50; } .block-portfolio-5 ol li:hover { color: #2d3e50; } .block-portfolio-5 ol li.active { background: #2d3e50; } .block-portfolio-5 .info:before { background: #2d3e50; } .block-portfolio-6 ol li:hover { color: #2d3e50; } .block-portfolio-6 ol li.active { background: #2d3e50; } .block-portfolio-6 ul a:before { background: #2d3e50; } .block-portfolio-7 ol li:hover { color: #2d3e50; } .block-portfolio-7 ol li.active { background: #2d3e50; } .block-portfolio-7 ul li:before { background: #2d3e50; } .block-portfolio-7 ul a:hover { color: #2d3e50; } .block-portfolio-8 li div:before { background: #2d3e50; } .block-portfolio-8 li a { background: #2d3e50; } .block-clients .owl-prev, .block-clients .owl-next { color: #2d3e50; } .block-testimonials-3 .carousel h3 { border-bottom-color: #2d3e50; } .block-testimonials-3 .owl-pagination div { border-color: #2d3e50; } .block-testimonials-3 .owl-pagination .active { background: #2d3e50; } .block-testimonials-4 .owl-prev, .block-testimonials-4 .owl-next { border-color: #2d3e50; background: #2d3e50; } .block-testimonials-4 .owl-prev:hover, .block-testimonials-4 .owl-next:hover { color: #2d3e50; } .block-services li a { border-color: #2d3e50; } .block-services li a:hover { background-color: #2d3e50; } .block-services-2 li a:hover { background: none; } .block-services-2 li a:after { box-shadow: inset 0 0 0 2px #2d3e50; } .block-services-2 li a:hover:after { background-color: #2d3e50; } .block-services-3 li a:hover { background: none; } .block-services-3 li a:after { box-shadow: inset 0 0 0 2px #2d3e50; } .block-services-3 li a:before { background: #2d3e50; box-shadow: inset 0 0 0 2px #2d3e50; } .block-services-3 li a:hover:after { background-color: #2d3e50; } .block-services-4 li a { border-color: #2d3e50; } .block-services-4 li a:hover { background-color: #2d3e50; } .block-services-5 li i { color: #2d3e50; } .block-services-5 li i:hover { background: #2d3e50; } .block-services-6 h3 span { color: #2d3e50; } .block-services-6 li a { border-color: #2d3e50; background: #2d3e50; } .block-services-6 li a:hover { color: #2d3e50; } .block-services-7 .info i { background: #2d3e50; } .block-services-7 .carousel .active { background: #2d3e50; } .block-services-7 .carousel .owl-prev, .block-services-7 .carousel .owl-next { border-color: #2d3e50; background: #2d3e50; } .block-services-7 .carousel .owl-prev:hover, .block-services-7 .carousel .owl-next:hover { color: #2d3e50; } .block-pricing dt { color: #2d3e50; } .block-pricing .price:before { background: #2d3e50; } .block-pricing li:hover .inner { background: #2d3e50; } .block-pricing li:hover .button { color: #2d3e50; } .block-pricing li:hover .button:hover { background: #2d3e50; } .page-content-section .block-pricing .inner { box-shadow: 0 0 0 1px #2d3e50; } .block-pricing-2 dt { color: #2d3e50; } .block-pricing-2 .price { background: #2d3e50; } .block-pricing-2 .button { color: #2d3e50; } .block-pricing-2 li:hover .inner { background: #2d3e50; } .block-pricing-2 li:hover .button:hover { background: #2d3e50; } .block-progress li i { border-color: #2d3e50; color: #2d3e50; } .block-team-2 .pic:before { background-color: #2d3e50; } .block-team-2 .icons a { color: #2d3e50; } .block-team-3 .pic:before { background-color: #2d3e50; } .block-team-3 .icons a { color: #2d3e50; } .block-team-3 .info h3 { color: #2d3e50; } .block-team-list .pic span:after { background-color: #2d3e50; } .block-team-list .icons a:hover { color: #2d3e50; } .block-team-list .icons a:before { background: #2d3e50; } .block-team-list .skills { border-top-color: #2d3e50; border-bottom-color: #2d3e50; } .block-team-grid .pic:before { background-color: #2d3e50; } .block-skills i:before { background-color: #2d3e50; } .block-skills .bar { border-color: #2d3e50; background-color: #2d3e50; } .block-skills-2 i:before { background-color: #2d3e50; } .block-skills-2 .bar { border-color: #2d3e50; background-color: #2d3e50; } .block-capabilities h3 { color: #2d3e50; } .block-capabilities-2 h3 { color: #2d3e50; } .block-recent-posts .info { background-color: #2d3e50; } .block-recent-posts-2:before { background-color: #2d3e50; } .block-recent-posts-2 li .button { color: #2d3e50; } .block-recent-posts-2 li .button:hover { background-color: #2d3e50; } .block-recent-posts-2 .button-more { color: #2d3e50; } .block-recent-posts-2 .button-more:hover { background-color: #2d3e50; } .block-featured-posts .pic:before { background-color: #2d3e50; } .block-blog-list .link { background: #2d3e50; } .block-blog-list .date:before { background-color: #2d3e50; } .block-blog-list .date-alt { background-color: #2d3e50; } .block-blog-list .zoom { background-color: #2d3e50; } .block-blog-grid .link { background: #2d3e50; } .block-blog-grid .date:before { background-color: #2d3e50; } .block-blog-grid .pic:hover .date { color: #2d3e50; } .block-blog-grid .zoom { color: #2d3e50; } .block-blog-details .date:before, .block-blog-details .reply:before, .block-blog-details .type:before { background-color: #2d3e50; } .block-blog-details .date-alt { background-color: #2d3e50; } .block-blog-details .share a:before { border-color: #2d3e50; background: #2d3e50; } .block-blog-details .share a:hover { color: #2d3e50; } .block-blog-details .about:before { background: #2d3e50; } .block-catalog-toolbar .view a:hover { border-color: #2d3e50; color: #2d3e50; } .block-catalog-toolbar .view .active, .block-catalog-toolbar .view .active:hover { border-color: #2d3e50; background: #2d3e50; } .block-catalog-toolbar .direction { border-color: #2d3e50; background: #2d3e50; } .block-catalog-toolbar .direction:hover { color: #2d3e50; } .block-catalog-grid .pic:before { background: #2d3e50; } .block-catalog-grid .badge { background: #2d3e50; } .block-catalog-grid .price { color: #2d3e50; } .block-catalog-grid .owl-prev, .block-catalog-grid .owl-next { border-color: #2d3e50; background: #2d3e50; } .block-catalog-grid .owl-prev:hover, .block-catalog-grid .owl-next:hover { color: #2d3e50;; } .block-catalog-list .pic:after { background-color: #2d3e50; } .block-catalog-list .badge:before { background-color: #2d3e50; } .block-catalog-list .price { color: #2d3e50; } .block-catalog-list .owl-prev, .block-catalog-list .owl-next { border-color: #2d3e50; background-color: #2d3e50; } .block-catalog-list .owl-prev:hover, .block-catalog-list .owl-next:hover { color: #2d3e50;; } .block-product-details .price { color: #2d3e50; } .block-product-details .button-alt { color: #2d3e50; } .block-product-details-2 .button-alt { color: #2d3e50; } .block-product-details-2 .share a:before { background-color: #2d3e50; box-shadow: 0 0 0 2px #2d3e50; } .block-product-details-2 .share a:hover { color: #2d3e50; } .block-product-info .owl-prev, .block-product-info .owl-next { border-color: #2d3e50; background-color: #2d3e50; } .block-product-info .owl-prev:hover, .block-product-info .owl-next:hover { color: #2d3e50; } .block-product-tabs .head .active { color: #2d3e50; } .block-product-tabs .head .active:before { border-top-color: #2d3e50; } .block-shopping-cart th { border-top-color: #2d3e50; color: #2d3e50; } .block-shopping-cart .price { color: #2d3e50; } .block-shopping-cart .remove { border-color: #2d3e50; background-color: #2d3e50; } .block-shopping-cart .remove:hover { color: #2d3e50; } .block-shopping-cart .quantity a { color: #2d3e50; } .block-shopping-cart .empty td { border-bottom-color: #2d3e50; } .block-shopping-cart-totals dd { color: #2d3e50; } .block-shopping-cart-totals .button-alt { color: #2d3e50; } .block-checkout-order td:last-child { color: #2d3e50; } .block-checkout-payment label { color: #2d3e50; } .block-welcome .icons i:after { border-color: #2d3e50; background: #2d3e50; } .block-welcome .icons a:hover i { color: #2d3e50; } .block-pasteboard:before { background: #2d3e50; } .block-pasteboard .icons a:hover { color: #2d3e50; } .block-map-3 .block-head { color: #2d3e50; } .block-contacts ul li:after, .block-contacts ul li:before { border-color: #2d3e50; background-color: #2d3e50; } .block-contacts ul li:before { background-color: #fff; } .block-contacts ul li span { border-bottom-color: #2d3e50; } .block-contacts ul .active { color: #2d3e50; } .block-contacts ul .active:before { background-color: #2d3e50; } .block-contacts ol { border-top-color: #2d3e50; } .block-contacts ol li { color: #2d3e50; } .block-contacts ol li i:after { background-color: #2d3e50; } .block-feedback .message i, .block-feedback-2 .message i { color: #2d3e50; } .block-not-found h3 { color: #2d3e50; } .block-not-found .pic:before { background-color: #2d3e50; } .block-not-found .pic div:before { background-color: #2d3e50; } .block-not-found-2 .button { color: #2d3e50; } .block-not-found-2 .button:hover { background: #2d3e50; } .block-coming-soon li:before { background-color: #2d3e50; } .block-coming-soon-2 li:after { background-color: #2d3e50; } .widget-categories a:hover, .widget-categories a.active { color: #2d3e50; } .widget-top-posts a:hover { color: #2d3e50; } .widget-text hr { border-top-color: #2d3e50; } .widget-text em { color: #2d3e50; } .widget-archive a:hover, .widget-archive a.active { color: #2d3e50; } .widget-tags a:hover { color: #2d3e50; } .widget-categories-filter a:hover { color: #2d3e50; } .widget-categories-filter .active { color: #2d3e50; } .widget-categories-filter .active span { background-color: #2d3e50; } .widget-price-filter .ui-slider-range { background-color: #2d3e50; } .widget-price-filter .ui-slider-handle { background-color: #2d3e50; } .widget-color-filter .active:before { border-color: #2d3e50; } .widget-top-products .pic i { background-color: #2d3e50; } .main-nav ul { background-color: #2d3e50; }