Charlotte Grove

Charlotte Grove


Start Year: 
2012
Department: 
550 First Ave
Institution: 
New York School of Medicine
Current Institution: 
New York School of Medicine

Homeotic (Hox) genes code for transcription factors in the hindbrain responsible for thepatterning or rhombomere (rh) formation and neuron identity. Yet, assigning an exactrole for an individual Hox gene in determining the structure/function of a given neuronalphenotype has been a longstanding challenge. To address this important question Iwill study Area II and inferior olive (IO) precerebellar hindbrain neurons whose activityis critical for horizontal oculomotor performance and plasticity. Specifically, the role ofHox4 in the acquisition of velocity sensitivity in precerbellar neurons will be probed ina transgenic zebrafish line in which a fluorescent protein, YFP, marks the expressionof Hox4. In larval and juvenile animals the spatial and temporal profile of Area II andIO neurons that express Hox4/YFP will be compared with those that don’t to assesswhether Hox4 is necessary for the acquisition of velocity sensitivity. Completion of thiswork will set the stage for studying oculomotor learning and memory that are entirelydependent on the Area II mossy and IO climbing fiber connections to the cerebellum.

Project Title: 

Homeotic genes and development of precerebellar neurons responsible for eye movement performance and plasticity

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